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Ipamorelin is a small synthetic peptide that stimulates the release of growth hormone from the pituitary gland without affecting other hormones such as cortisol or
prolactin. It works by binding to the ghrelin receptor (GHS-R1a) with high
affinity and selectivity, mimicking the natural hunger signal but in a controlled manner.

When ipamorelin is injected, it triggers the secretion of growth hormone in pulses that resemble the body’s normal rhythm,
which helps preserve metabolic balance and reduces side effects
often seen with other growth hormone secretagogues.



Ipamorelin + CJC 1295 Stack: The Dynamic Duo

When ipamorelin is paired with CJC-1295, a long-acting growth hormone releasing peptide (GHRP), the combination becomes especially powerful.

CJC-1295 contains a hexapeptide that binds to the same ghrelin receptor but has an extended
half-life due to a polyethylene glycol (PEG) moiety; this prolongs its action for up to 24 hours.
By administering both peptides, users obtain rapid, high peaks of growth hormone from
ipamorelin together with sustained baseline levels provided by CJC-1295.
The result is a steady state of elevated growth hormone and insulin-like growth factor 1 (IGF-1) throughout the day
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reviews before and after night, which can enhance muscle protein synthesis, fat oxidation, tissue repair, and
overall cellular rejuvenation. This stack is often called "The Dynamic Duo" because it combines
the quick onset of ipamorelin with the long-lasting effect of CJC-1295, producing a synergistic response that many athletes, bodybuilders, and anti-aging enthusiasts seek.




Key Takeaways





Ipamorelin selectively stimulates growth hormone release through the
ghrelin receptor without altering cortisol or prolactin levels.




It produces natural pulsatile peaks that align with the body’s circadian rhythm, minimizing hormonal disruption.


When stacked with CJC-1295, ipamorelin delivers sharp spikes of growth hormone while CJC-1295 maintains a
prolonged release, creating a stable environment
for anabolic processes.


The combination can improve lean muscle mass, reduce visceral fat,
accelerate recovery from exercise, and support tissue repair and regeneration.


Because both peptides are peptide hormones, they require parenteral administration (usually subcutaneous injections) and should
be used under professional guidance to ensure proper dosing and monitoring of hormone levels.

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